Grdina Lab

People

The lab is under the leadership of Professor David Grdina, an expert in the field of radiation biophysics. He completed his doctoral training at the University of Kansas in 1971 and has been working with the University of Chicago since 1985.

In addition to Dr. Grdina, Dr. Jeffrey S. Murley, Dr. Richard C. Miller and Mr. Ken Baker work in the lab. 

Research

Currently, the Grdina lab's research is focused on two main goals. First, the Department of Energy has funded a project investigating adaptive responses induced by either very low doses of ionizing radiation or by thiol containing cytoprotective drugs. This research has implications for patient response to therapy and to environmental risk assessment. The Grdina lab's exploration of this area could lead to increased survival of healthy cells.

Additionally, the National Institutes of Health and the National Cancer Institute have funded research into a novel concept of therapy coupled chemoprevention. In this study, therapeutic agents with carcinogenic potential are paired with anti-mutagenic or anti-carcinogenic drugs in order to discover a way to reduce the risk of therapy-induced secondary cancers in otherwise healthy patients.

Recent Publications

  • Murley, JS, KL Baker, RC Miller, TE Darga, RR Weichselbaum, DJ Grdina. SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine. Free Radical Biol. Med. 51: 1918-1925, 2011. PubMed.
  • Fu, P, JS Murley, DJ Grdina, AA Birukova, KG Birukov. Induction of cellular antioxidant defense by amifostine improves ventilator-induced lung injury. Crit. Care Med. 39(12):2711-2721, 2011. PubMed.
  • Murley, JS, Y Kataoka, RC Miller, JJ Li, G Woloschak, DJ Grdina. SOD2-mediated effects induced by WR1065 and low-dose ionizing radiation on micronucleus formation in RKO human colon carcinoma cells. Radiat. Res., 175: 57-65, 2011. PubMed.
  • Dziegielewski, J, W Goetz, JS Murley, DJ Grdina, WF Morgan, and JE Baulch. Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells. Radiat. Res., 173: 175-183, 2010. PubMed.
  • Ahmed, KM, D Natajit, M Fan, JS Murley, DJ Grdina, JJ Li. Co-activation of ATM/ERK/NF-kB in Low Dose Radiation-Induced Adaptive Radioresistance in Human Skin Keratinocytes. Free Radical Biol. Med., 46 (11):1543-1550, 2009. PubMed.